This guide discusses chromosomal abnormalities and how best to report and communicate lab findings in research and clinical settings. Providing a standard approach to writing cytogenetic laboratory reports, the guide further covers useful guidance on implementing International System for Human Cytogenetic Nomenclature in reports. Part one of the guide explores chromosomal, FISH, and microarray analysis in constitutional cytogenetic analyses, while part two looks at acquired abnormalities in cancers. Both sections provide illustrative examples of chromosomal abnormalities and how to communicate these findings in standardized laboratory reports.
Written by a team of international experts, this book provides an authoritative overview and practical guide to the molecular biology and genetic basis of haematologic cancers including leukemia. Focusing on the importance of cytogenetics and related assays, both as diagnostic tools and as a basis for translational research, this is an invaluable guide for basic and clinical researchers with an interest in medical genetics and haemato-oncology. The Genetic Basis of Haematological Cancers reviews the etiology and significance of genetic and epigenetic defects that occur in malignancies of the haematopoietic system. Some of these chromosomal and molecular aberrations are well established and already embedded in clinical management, while many others have only recently come to light as a result of advances in genomic technology and functional investigation. The book includes seven chapters written by clinical and academic leaders in the field, organised according to haematological malignancy sub-type. Each chapter includes a background on disease pathology and the genetic abnormalities most commonly associated with the condition. Authors present in-depth discussions outlining the biological significance of these lesions in pathogenesis and progression, and their use in diagnosis and monitoring response to therapy. The current or potential role of specific abnormalities as novel therapeutic targets is also discussed. There is also a full colour section containing original FISH, microarrays and immunostaining images.
Written by senior clinicians across a range of specialties, Data Interpretation for Medical Finals: Single Best Answer Questions is the perfect way to prepare for data interpretation assessments and clinical practice. Featuring over 200 questions on key topics in medicine, each question is set around an image or investigation, such as an X-ray, CT scan, or blood film, and tests identification and interpretation of the data provided. Thorough explanation of the correct and incorrect answers helps you learn from mistakes. The questions reflect current exam question style and incorporate high quality images, many of which are annotated, and are presented in full colour throughout. Data Interpretation for Medical Finals will help build the confidence of all medical students, and Foundation Doctors, as it encourages application of investigation results to clinical decision making.
Using examples and case studies from industry, academia and research literature, Randomized Clinical Trials provides a detailed overview of the key issues involved in designing, conducting, analysing and reporting randomized clinical trials. It examines the methodology for conducting Phase III clinical trials, developing the protocols, the practice for capturing, measuring, and analysing the resulting clinical data and their subsequent reporting. Randomized clinical trials are the principal method for determining the relative efficacy and safety of alternative treatments, interventions or medical devices. They are conducted by groups comprising one or more of pharmaceutical and allied health-care organisations, academic institutions, and charity supported research groups. In many cases such trials provide the key evidence necessary for the regulatory approval of a new product for future patient use. Randomized Clinical Trials provides comprehensive coverage of such trials, ranging from elementary to advanced level. Written by authors with considerable experience of clinical trials, Randomized Clinical Trials is an authoritative guide for clinicians, nurses, data managers and medical statisticians involved in clinical trials research and for health care professionals directly involved in patient care in a clinical trial context.
Exploit the full potential of the WPPSI-IV with analysis from multiple perspectives Essentials of WPPSI-IV Assessment is a comprehensive guide to administering, scoring, and interpreting the latest edition of the Wechsler Preschool and Primary Scale of Intelligence, which represents a major revision of the prior edition. Step-by-step guidelines walk readers through the process, and new Behind the Scenes boxes provide unprecedented insight into the new subtests and the test development process. The book highlights common errors and complex aspects so readers can avoid them, and includes illustrative case studies based on data collected during the scale's standardization to assist in proper administration and interpretation. The companion CD provides software that automates score interpretation, and supplies users with tools to enhance WPPSI-IV administration and report writing. Used to evaluate for learning or intellectual disabilities, developmental or language delays, or gifted and talented classification, the Wechsler Preschool and Primary Scale of Intelligence is the most widely used assessment of intelligence for young children. Essentials of WPPSI-IV Assessment applies an interpretive approach that allows flexibility in response to the real constraints and challenges inherent in working with children, describing performance in both normative and interpersonal contexts to facilitate interpretive case formulations from multiple theoretical and clinical perspectives. Topics include: WPPSI-IV administration and clinical applications Scoring, score analysis, and interpretation Strengths and weaknesses of the WPPSI-IV Differences across demographic groups The book and accompanying CD also provide alternatives for situations in which published comparison scores may not be available or applicable to a particular child, and supplies composite scores aimed at facilitating WPPSI-IV interpretation from a variety of theoretical approaches. Those who employ the WPPSI-IV must have a thorough grasp of the full potential of the tool, and Essentials of WPPSI-IV Assessment contains the insight and information that allow for deeper understanding.
The International Financial Reporting Standards are quite different from other sets of accounting standards, and are fundamentally different from US-GAAP, in that they are based on principles, and not on detailed rules. Financial Reporting under IFRS:A topic-based approach offers a global perspective on IFRS by presenting the prescribed rationale and principles and illustrating them through numerous examples from large international companies. It aims to develop the fundamental skills necessary to read and use the information contained in all types of financial statements, through examples, activities, questions and answers. The book is broadly divided into three sections. Section one examines the structure of the Balance Sheet and the Income Statement, their links and the accounting mechanisms used to prepare them. Section two deals with the identification, evaluation and reporting of Balance Sheet items. Section three covers the use of financial statements to analyze a firm’s performance and its risks. Throughout the book special topics are covered, including Derivatives and Hedge accounting (IAS 39), Business Combination (IFRS 3) and Operating Segments (IFRS 8). Financial Reporting under IFRS is ideally suited to the needs of students of accounting and financial reporting, but all users of financial statements, from creditors and investors to suppliers, customers, employees and governments will benefit from its concise, topic-based approach.
Clinical Cases in Avian and Exotic Animal Hematology and Cytology demonstrates how to use hemic cytology and cytodiagnosis as part of the assessment of an exotic animal patient, taking the reader through nearly 100 actual clinical cases. With a focus on cytological interpretation, the hands-on, practical approach facilitates learning, teaching, and comprehension. Well illustrated throughout, Clinical Cases in Avian and Exotic Animal Hematology and Cytology is a helpful guide for exotics veterinarians, zoo and aquarium veterinarians, and veterinary hematologists.
Competency-Based Assessments in Mental Health Practice should be required reading for all clinical practitioners and students. Author Susan W. Gray provides a competency-based assessment model that moves away from looking at mental illness as a 'disease' to capturing people's strengths and the uniqueness of their experience with mental illness. —Alex Gitterma Zachs Professor and Director of PhD Program «Competency-Based Assessment in Mental Health Practice not only describes the rather cumbersome DSM-IV-TR® in a manner that graduate students and clinicians can easily understand and apply, but it also presents a competency-based type of clinical assessment that most effectively integrates the social work practice orientation that acknowledges, appreciates, and nurtures client strengths, resilience, and client ability for empowerment.» —Agathi Glezakos, PhD, LCSW School of Social Work California State University, Long Beach A competency-based assessment model integrating DSM classifications for a complete, strengths-based diagnosis Competency-Based Assessments in Mental Health Practice introduces a unique, competency-based assessment that presents a brief overview of the major mental disorders that practitioners will likely encounter in their work with clients, followed by a series of case studies and practical applications. This book provides valuable guidance for clinicians to make assessments grounded in client strengths and possibilities for a more therapeutically complete picture of every client's «story.» Organized around selected diagnostic categories from the DSM-IV-TR, this hands-on guide offers a multidimensional look at the many factors that play a role in a client's life. Its holistic approach to the assessment process considers each client's unique experience with mental illness, through a concurrent evaluation of strengths and pathology, in order to set the stage for realistic optimism about the potential for change.
Best practices for conducting effective and safe clinical trials Clinical trials are arguably the most important steps in proving drug effectiveness and safety for public use. They require intensive planning and organization and involve a wide range of disciplines: data management, biostatistics, pharmacology, toxicology, modeling and simulation, regulatory monitoring, ethics, and particular issues for given disease areas. Clinical Trials Handbook provides a comprehensive and thorough reference on the basics and practices of clinical trials. With contributions from a range of international authors, the book takes the reader through each trial phase, technique, and issue. Chapters cover every key aspect of preparing and conducting clinical trials, including: Interdisciplinary topics that have to be coordinated for a successful clinical trialData management (and adverse event reporting systems) Biostatistics, pharmacology, and toxicology Modeling and simulation Regulatory monitoring and ethics Particular issues for given disease areas-cardiology, oncology, cognitive, dementia, dermatology, neuroscience, and more With unique information on such current issues as adverse event reporting (AER) systems, adaptive trial designs, and crossover trial designs, Clinical Trials Handbook will be a ready reference for pharmaceutical scientists, statisticians, researchers, and the many other professionals involved in drug development.
Hemostasis and Thrombosis: Practical Guidelines in Clinical Management Edited by Hussain I Saba MD, PhD Professor of Medicine Director of Hematology/Hemophilia/Hemostasis & Thrombosis Center USF College of Medicine Professor Emeritus Department of Malignant Hematology Moffitt Cancer Center and Research Institute Tampa, FL, USA Harold R Roberts MD Emeritus Professor of Medicine and Pathology Division of Hematology / Oncology University of North Carolina Chapel Hill, NC, USA Hemostasis and thrombosis is a hugely important, changing and complex area that impacts many other medical specialties, affecting at least 10 million people in the United States alone. It is vital for physicians to recognize abnormalities of hemostasis and thrombosis and to be able to address these problems in their patients. Hemostasis and Thrombosis: Practical Guidelines in Clinical Managementcovers all aspects of the practical management of commonly encountered thrombotic and bleeding disorders, with emphasis on clinical diagnosis, treatment, and day-to-day management. The most clinically relevant material from the literature has been carefully compiled, along with: – Discussions of new and upcoming diagnostic and therapeutic modalities – Practical clinical advice for all those dealing with coagulation, hemostasis and thrombosis Written by world leading specialists contributing their expertise in succinct text and focusing on the latest clinical guidance, Hemostasis and Thrombosis: Practical Guidelines in Clinical Management will benefit hematologists in training and in practice working in the fields of coagulation, hemostasis and thrombosis. Titles of related interest Practical Hemostasis and Thrombosis, 2nd Edition Key, ISBN 9781405184601 Hemophilia and Hemostasis: A Case-Based Approach to Management, 2nd Edition Ma, ISBN 9780470659762 Quality in Laboratory Hemostasis and Thrombosis, 2nd Edition Kitchen, ISBN 9780470671191 www.wiley.com/go/hematology